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1

SUN-190 GFB-887, a small molecule inhibitor of TRPC5, protects against podocyte injury and attenuates proteinuria in models of FSGS

MUNDEL, P., Westerling-Bui, A., Ledeboer, M., Coeffet-Le Gal, M., Pan-Zhou, X.R., Yu, M., Daniels, M., Plato, C., Harmange, J.C., Reilly, J.

Journal:

Kidney International Reports

Year:

2019

Language:

english

File:

PDF, 124 KB

english, 2019

2

Stereospecific synthesis of (+)-muricatacin: a biologically active acetogenin derivative

B. Figadère, J-C. Harmange, A. Laurens, A. Cavé

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 280 KB

english, 1991

3

Stereocontrolled synthesis of 2,5-linked monotetrahydrofuran units of acetogenins

Jean-Christophe Harmange, Bruno Figadère, André Cavé

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 238 KB

english, 1992

4

Relative and absolute stereochemistry of the fumonisin B2 backbone

Jean-Christophe Harmange, Craig D. Boyle, Yoshito Kishi

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 311 KB

english, 1994

5

Discovery of novel 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydroisoquinoline-1(2H)-ones as potent and selective inhibitors of KDR: Synthesis, SAR, and pharmacokinetic properties

Deborah Choquette, Yohannes Teffera, Anthony Polverino, Jean-Christophe Harmange

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 258 KB

english, 2008

6

Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead

H. Du, T. Matsushima, M. Spyvee, M. Goto, H. Shirota, F. Gusovsky, K. Chiba, M. Kotake, N. Yoneda, Y. Eguchi, L. DiPietro, J.-C. Harmange, S. Gilbert, X.-Y. Li, H. Davis, Y. Jiang, Z. Zhang, R. Pellet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 633 KB

english, 2009

7

Evaluation of indazole-based compounds as a new class of potent KDR/VEGFR-2 inhibitors

David Bauer, Douglas A. Whittington, Angela Coxon, James Bready, Shawn P. Harriman, Vinod F. Patel, Anthony Polverino, Jean-Christophe Harmange

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 336 KB

english, 2008

8

Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant α4β2 nicotinic acetylcholine receptor potentiators

Brian K. Albrecht, Virginia Berry, Alessandro A. Boezio, Lei Cao, Kristie Clarkin, Wenhong Guo, Jean-Christophe Harmange, Markus Hierl, Liyue Huang, Brett Janosky, Johannes Knop, Annika Malmberg, Jeff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 221 KB

english, 2008

9

Synthesis and activity of substituted carbamates as potentiators of the α4β2 nicotinic acetylcholine receptor

Stephanie K. Springer, Katrina S. Woodin, Virginia Berry, Alessandro A. Boezio, Lei Cao, Kristie Clarkin, Jean-Christophe Harmange, Markus Hierl, Johannes Knop, Annika B. Malmberg, Jeff S. McDermott,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 238 KB

english, 2008

10

Corrigendum to “synthesis and activity of substituted carbamates as potentiators of the α4β2 nicotinic acetylcholine receptor” [Bioorg. Med. Chem. Lett. 18 (2008) 5643–5647]

Stephanie K. Springer, Katrina S. Woodin, Virginia Berry, Alessandro A. Boezio, Lei Cao, Kristie Clarkin, Jean-Christophe Harmange, Markus Hierl, Johannes Knop, Annika B. Malmberg, Jeff S. McDermott,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 105 KB

english, 2009

11

Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors

John L. Buchanan, John R. Newcomb, David P. Carney, Stuart C. Chaffee, Lilly Chai, Rod Cupples, Linda F. Epstein, Paul Gallant, Yan Gu, Jean-Christophe Harmange, Kathy Hodge, Brett E. Houk, Xin Huang,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.79 MB

english, 2011

12

Synthetic routes to 2,5-disubstituted tetrahydrofurans

Jean-C. Harmange, Bruno Figadère

Journal:

Tetrahedron: Asymmetry

Year:

1993

Language:

english

File:

PDF, 2.03 MB

english, 1993

13

Enantiospecific preparation of the lactone fragment of murisolin

Jean-Christophe Harmange, Bruno Figadère, Reynald Hocquemiller

Journal:

Tetrahedron: Asymmetry

Year:

1991

Language:

english

File:

PDF, 242 KB

english, 1991

14

Catalytic hydrogenation of annonaceous acetogenins

Diego Cortes, Saw H. Myint, Jean C. Harmange, Sevser Sahpaz, Bruno Figadere

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 150 KB

english, 1992

15

Synthesis of 2,33-dihydro-4-oxo-murisolin : Conjugate addition of primary alkyl iodides to α,β-unsaturated ketones

Bruno Figadère, Jean-Christophe Harmange, Liu Xiao Hai, André Cavé

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 261 KB

english, 1992

16

Study of the structure-activity relationships of the acetogenin of annonaceae, muricatacin and analogues

A Cavé, C Chaboche, B Figadère, J.C. Harmange, A Laurens, J.F. Peyrat, M Pichon, M Szlosek, J Cotte-Lafitte, A.M. Quéro

Journal:

European Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 626 KB

english, 1997

17

Chemical Reactivity of Methoxy 4-O-Aryl Quinolines: Identification of Glutathione Displacement Products in Vitro and in Vivo

Teffera, Yohannes, Colletti, Adria E., Harmange, Jean Christophe, Hollis, L. Steven, Albrecht, Brian K., Boezio, Alessandro A., Liu, Jingzhou, Zhao, Zhiyang

Journal:

Chemical Research in Toxicology

Year:

2008

Language:

english

File:

PDF, 945 KB

english, 2008

18

Discovery and Optimization of a Novel Series of N-Arylamide Oxadiazoles as Potent, Highly Selective and Orally Bioavailable Cannabinoid Receptor 2 (CB2) Agonists

Cheng, Yuan, Albrecht, Brian K., Brown, James, Buchanan, John L., Buckner, William H., DiMauro, Erin F., Emkey, Renee, Fremeau, Robert T., Harmange, Jean-Christophe, Hoffman, Beth J.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 774 KB

english, 2008

19

Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase †

Albrecht, Brian K., Harmange, Jean-Christophe, Bauer, David, Berry, Loren, Bode, Christiane, Boezio, Alessandro A., Chen, April, Choquette, Deborah, Dussault, Isabelle, Fridrich, Cary, Hirai, Satoko,

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 729 KB

english, 2008

20

Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors

Potashman, Michele H., Bready, James, Coxon, Angela, DeMelfi,, Thomas M., DiPietro, Lucian, Doerr, Nicholas, Elbaum, Daniel, Estrada, Juan, Gallant, Paul, Germain, Julie, Gu, Yan, Harmange, Jean-Chris

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 673 KB

english, 2007

21

Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors

Gehling, Victor S., Hewitt, Michael C., Vaswani, Rishi G., Leblanc, Yves, Côté, Alexandre, Nasveschuk, Christopher G., Taylor, Alexander M., Harmange, Jean-Christophe, Audia, James E., Pardo, Eneida,

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 397 KB

english, 2013

22

Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and Evaluation ¶

Harmange, Jean-Christophe, Weiss, Matthew M., Germain, Julie, Polverino, Anthony J., Borg, George, Bready, James, Chen, Danlin, Choquette, Deborah, Coxon, Angela, DeMelfi, Tom, DiPietro, Lucian, Doerr

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.38 MB

english, 2008

23

Evaluation of a Series of Naphthamides as Potent, Orally Active Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitors ¶

Weiss, Matthew M., Harmange, Jean-Christophe, Polverino, Anthony J., Bauer, David, Berry, Loren, Berry, Virginia, Borg, George, Bready, James, Chen, Danlin, Choquette, Deborah, Coxon, Angela, DeMelfi,

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 777 KB

english, 2008

24

Novel Structure Elucidation of AAL Toxin TA Backbone

Boyle, Craig D., Harmange, Jean-Christophe, Kishi, Yoshito

Journal:

Journal of the American Chemical Society

Year:

1994

Language:

english

File:

PDF, 251 KB

english, 1994

25

A Practical Synthesis of Indoles via a Pd-Catalyzed C–N Ring Formation

Vaswani, Rishi G., Albrecht, Brian K., Audia, James E., Côté, Alexandre, Dakin, Les A., Duplessis, Martin, Gehling, Victor S., Harmange, Jean-Christophe, Hewitt, Michael C., Leblanc, Yves, Nasveschuk,

Journal:

Organic Letters

Year:

2014

Language:

english

File:

PDF, 442 KB

english, 2014

26

Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors

Potashman, Michele H., Bready, James, Coxon, Angela, DeMelfi, Thomas M., DiPietro, Lucian, Doerr, Nicholas, Elbaum, Daniel, Estrada, Juan, Gallant, Paul, Germain, Julie, Gu, Yan, Harmange, Jean-Christ

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 29 KB

english, 2008

27

Discovery of Benzotriazolo[4,3- d ][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains

Taylor, Alexander M., Vaswani, Rishi G., Gehling, Victor S., Hewitt, Michael C., Leblanc, Yves, Audia, James E., Bellon, Steve, Cummings, Richard T., Côté, Alexandre, Harmange, Jean-Christophe, Jayara

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 667 KB

english, 2015

28

Development of methyl isoxazoleazepines as inhibitors of BET

Hewitt, Michael C., Leblanc, Yves, Gehling, Victor S., Vaswani, Rishi G., Côté, Alexandre, Nasveschuk, Christopher G., Taylor, Alexander M., Harmange, Jean-Christophe, Audia, James E., Pardo, Eneida,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 726 KB

english, 2015

29

Corrigendum to “Development of methyl isoxazoleazepines as inhibitors of BET” [Bioorg. Med. Chem. Lett. 25/9 (2015) 1842–1848]

Hewitt, Michael C., Leblanc, Yves, Gehling, Victor S., Vaswani, Rishi G., Côté, Alexandre, Nasveschuk, Christopher G., Taylor, Alexander M., Harmange, Jean-Christophe, Audia, James E., Pardo, Eneida,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 175 KB

english, 2015

30

Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies

Liang, Jun, Zhang, Birong, Labadie, Sharada, Ortwine, Daniel F., Vinogradova, Maia, Kiefer, James R., Gehling, Victor S., Harmange, Jean-Christophe, Cummings, Richard, Lai, Tommy, Liao, Jiangpeng, Zhe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 798 KB

english, 2016

31

Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors

Labadie, Sharada S., Dragovich, Peter S., Cummings, Richard T., Deshmukh, Gauri, Gustafson, Amy, Han, Ning, Harmange, Jean-Christophe, Kiefer, James R., Li, Yue, Liang, Jun, Liederer, Bianca M., Liu,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 706 KB

english, 2016

32

Identification of potent, selective KDM5 inhibitors

Gehling, Victor S., Bellon, Steven F., Harmange, Jean-Christophe, LeBlanc, Yves, Poy, Florence, Odate, Shobu, Buker, Shane, Lan, Fei, Arora, Shilpi, Williamson, Kaylyn E., Sandy, Peter, Cummings, Rich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.76 MB

english, 2016

33

From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors

Liang, Jun, Labadie, Sharada, Zhang, Birong, Ortwine, Daniel F., Patel, Snahel, Vinogradova, Maia, Kiefer, James R., Mauer, Till, Gehling, Victor S., Harmange, Jean-Christophe, Cummings, Richard, Lai,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 1.14 MB

english, 2017

34

Differences in home-range sizes of a bird species in its original, refuge and substitution habitats: challenges to conservation in anthropogenic habitats

Godet, Laurent, Harmange, Clément, Marquet, Matthieu, Joyeux, Emmanuel, Fournier, Jérôme

Journal:

Biodiversity and Conservation

Year:

2017

Language:

english

File:

PDF, 1019 KB

english, 2017

35

SCoPE-MS: mass spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation

Budnik, Bogdan, Levy, Ezra, Harmange, Guillaume, Slavov, Nikolai

Journal:

Year:

2018

Language:

english

File:

PDF, 2.31 MB

english, 2018

36

Changes in habitat selection patterns of the gray partridge Perdix perdix in relation to agricultural landscape dynamics over the past two decades

Harmange, Clément, Bretagnolle, Vincent, Sarasa, Mathieu, Pays, Olivier

Journal:

Ecology and Evolution

Year:

2019

Language:

english

File:

PDF, 785 KB

english, 2019

37

Syntheses of Complex Terpenes from Simple Polyprenyl Precursors

Harmange Magnani, Claire S., Thach, Danny Q., Haelsig, Karl T., Maimone, Thomas J.

Journal:

Accounts of Chemical Research

Year:

2020

Language:

english

File:

PDF, 2.57 MB

english, 2020

38

Interspecific competition between two partridges in farmland landscapes

Rinaud, Tony, Harmange, ClÃ©ment, Pays, Olivier, Sarasa, Mathieu, Saillard, Maxime, Bretagnolle, Vincent

Journal:

Animal Behaviour

Year:

2020

File:

PDF, 815 KB

2020

39

Fusicoccin Keeps Getting Stickier: Modulation of an Adaptor Protein Interactome with a Molecular Glue Leads to Neurite Outgrowth

Harmange Magnani, Claire S., Maimone, Thomas J.

Journal:

Cell Chemical Biology

Year:

2020

File:

PDF, 963 KB

2020

40

Memory Sequencing Reveals Heritable Single-Cell Gene Expression Programs Associated with Distinct Cellular Behaviors

Shaffer, Sydney M., Emert, Benjamin L., Reyes Hueros, RaÃºl A., Cote, Christopher, Harmange, Guillaume, Schaff, Dylan L., Sizemore, Ann E., Gupte, Rohit, Torre, Eduardo, Singh, Abhyudai, Bassett, Dani

Journal:

Year:

2020

File:

PDF, 18.67 MB

2020

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